| Alabama | Not yet specified | 3, 4, 5, 6, 7, 8 | Not yet specified | - |
| Alaska | Not yet specified | 4, 8 | Comprehensive | 10 |
| Arizona | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Arkansas | Not yet specified | Grades not specified | Not yet specified | - |
| California | Cumulative across grade-span | 5, 8 | Neither Comprehensive or EOC | The assessment will be given at grade that student completes science coursework in high school. |
| Colorado | Not yet specified | 5, 8 | Comprehensive | Not reported |
| Connecticut | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Delaware | Specific grade-level content | 5, 8 | End-of-Course | Biology |
| District of Columbia | Cumulative across grade-span | 5, 8 | End-of-Course | Biology |
| Georgia | Specific grade-level content | 5, 8 | End-of-Course | Biology, Physical Science |
| Hawaii | Cumulative across grade-span | 5, 8 | End-of-Course | Biology 1 |
| Idaho | Cumulative across grade-span | 5, 8 | Comprehensive | Proposed to administer in grade 11 but not finalized |
| Indiana | Specific grade-level content | 4, 6 | End-of-Course | Biology |
| Iowa | Cumulative across grade-span | 5, 8 | Comprehensive | 10 |
| Kansas | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Kentucky | Cumulative across grade-span | 4, 7 | End-of-Course | Statewide field test completed in Biology in spring 2018, but final decision of a comprehensive or EOC assessment is not finalized for 2018-19. |
| Louisiana | Specific grade-level content | 3, 4, 5, 6, 7, 8 | End-of-Course | Biology |
| Maine | Cumulative across grade-span | 5, 8 | Comprehensive | Administered the 3rd year of high school. |
| Maryland | Cumulative across grade-span | 5, 8 | Comprehensive | 10 or 11 depending on courses taken |
| Massachusetts | Cumulative across grade-span | 5, 8 | End-of-Course | To be determined, will have Biology and Introductory Physics |
| Michigan | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Minnesota | Cumulative across grade-span | 5, 8 | Not yet specified | - |
| Mississippi | Specific grade-level content | 5, 8 | End-of-Course | Biology I |
| Montana | Not yet specified | 4, 8 | Not yet specified | - |
| Nebraska | Cumulative across grade-span | 5, 8 | End-of-Course | By legislative statute, our HS exam must be a college admissions test. We currently have a contract with ACT. |
| Nevada | Specific grade-level content | 5, 8 | Comprehensive | 10 |
| New Hampshire | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| New Mexico | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| New York | Not yet specified | 5, 8 | End-of-Course | Not reported |
| North Carolina | Not yet specified | Grades not specified | Not yet specified | - |
| North Dakota | Not yet specified | 4, 8 | Comprehensive | Not reported |
| Ohio | Specific grade-level content | 5, 8 | End-of-Course | Biology |
| Oklahoma | Specific grade-level content | 5, 8 | Comprehensive | 11 |
| Oregon | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Pennsylvania | - | - | Not yet specified | - |
| Rhode Island | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| South Dakota | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Tennessee | Specific grade-level content | 3, 4, 5, 6, 7, 8 | End-of-Course | Biology |
| Utah | Specific grade-level content | 6, 7, 8 | Comprehensive | 9 |
| Vermont | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Virginia | Not yet specified | Grades not specified | End-of-Course | Earth Science, Biology, Chemistry currently and this may change. |
| Washington | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| West Virginia | Cumulative across grade-span | 5, 8 | Comprehensive | 11 |
| Wisconsin | Cumulative across grade-span | 4, 8 | Comprehensive | 11 |
| Wyoming | Specific grade-level content | 4, 8 | Comprehensive | Modified comprehensive of selected performance expectations administered in 10th grade |
